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This article was originally written for a paranormal magazine called The Paranormal Journal, it became known as The Underground Files covering ghosts, ufos, cryptozoology, and government conspiracies amongst others. I no longer write for the magazine and it is no longer in existence. Genetic Code for Obsessive-Compulsive Disorder U.S. and Japanese researchers have found the genetic mutation code for the syndrome of Obsessive-Compulsive Disorder, they said on Thursday, 23 October 2003. Not to be left alone on the shelf they reckon this gene could be responsible for other mental illnesses, and some patients had a second mutation that made their conditions worse. The finding could make it easier to find better treatments for the disorder, considered one of the top 10 leading causes of disability worldwide. Dr Norio Ozaki of Fujita Health University School of Medicine in Toyoake, Japan and colleagues at several U.S. institutions, including the University of Pittsburgh and Yale Universities, worked on the study in the journal Molecular Psychiatry. The gene is called the human serotonin transporter gene, hSert, and helps to control how the body uses serotonin, a message carrying chemical or neurotransmitter linked to mood. Some anxiety drugs and antidepressants target serotonin, but the researchers said patients with mutations are not helped by these drugs. “In all of molecular medicine, there are few known instances where two variants within one gene have been found to alter the expression and regulation of the gene in a way that appears associated with symptoms of a disorder,” said Dr. Dennis Murphy of the National Institute of Mental Health, who worked on the study. The researchers analysed genes from 170 people, including 30 patients with obsessive-compulsive disorder (OCD), 30 with eating disorders, and 30 with seasonal affective disorder, which can cause depression and other disorders in dark winter months. They also looked at the genes of 80 healthy people. A specific mutation in hSert gene was seen in two patients with OCD and their families, but not in other patients. The researchers believe the deformed gene to be present in other families suffering from these conditions. They interviewed relatives
of the patients and found 6 of the 7 people with the mutation had an
obsessive-compulsive disorder, some also had anorexia, Asperger’s syndrome,
which is a form of autism, social phobias or were users of alcohol. The patients and their siblings had especially difficult to treat versions of OCD, the researchers said. Genetic Code for Obsessive-Compulsive Disorder written by Bill Barber |
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